OP-3：The Association of hOGG1 C1245G Polymorphism with Insulin Sensitivity in Non-diabetic Subjects

CL Wang, MC Hsieh, HY Lin, SC Hsin, SJ Shin

Division of Endocrinology & Metabolism, Graduate Institute of Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan

Accumulation of reactive oxygen species (ROS) has been thought as the pathogenetic factor of insulin resistance and the development of diabetes. Activated oxidative DNA damage is also observed in diabetic patients with vascular complications. The DNA repair activity of human 8-oxoguanine glycosylase (hOGG1) C1245G GG genotype to remove 8-OHdG is lower than CC genotype. We hypothesized that hOGG 1 gene polymorphism is associated with insulin sensitivity in non-diabetic subjects. Four hundred ninety-two Type 2 diabetic patients and 317 non-diabetic subjects were studied. Polymorphism of hOGG1 C1245G was measured by PCR-RFLP. The frequency (p<0.005) of CC, CG, and GG in non-diabetic subjects and diabetic patients are 25.2% vs 16.3 %, 45.4% vs 48.0 %, and 29.3% vs 35.8%. In 171 non-diabetic subjects, the value of HOMA-insulin resistance of 67 subjects with GG genotype is significantly higher than that 34 with CC and 70 with CG genotype while fasting plasma glucose and blood pressure are not significantly different among three groups. These results indicate that hOGG1 C1245G gene polymorphism may be a pathogenetic risk factor of insulin resistance and is also associated with the development of diabetes.

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